Deep Cholesterol Binding Sites    Anthony Lee - University of Southampton

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Deep Cholesterol Binding Sites

• Introduction
• GPCR Class A
• Rhodopsin and Opsin
• GPCR Class B
• GPCR Class C
• GPCR Class F
• Adiponectin Receptor
• Ion Channels
• Porins Etc.
• Transporters
• Other Membrane Proteins

Interfacial Cholesterol Binding Sites

• GPCR Class A [Part 1]
• GPCR Class A [Part 2]
• GPCR Class B
• GPCR Class C
• GPCR Class F
• Adiponectin Receptor
• TRPA-TRPN channels
• TRPP-TRPV channels

Deep Cholesterol Binding Sites on Mammalian Membrane Proteins

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GPCRs Class C

[With residue numbers in the Pin numbering system; Units of E, kcals/mol with molar concentration units]

E	Donor		Acceptor		Local Residues (within 3 Å of a cholesterol –OH group)
Metabotropic glutamate receptor 1, Human 4or2
-5.7	Chl	OH	Ser715 [4.41]	OG	Ser715 [4.41]	Thr719 [4.45]
	Chl	OH	Thr719 [4.45]	OG1
Metabotropic glutamate receptor 5, Human  4oo9
None

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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